The renal handling of amphotericin B and amphotericin B / deoxycholate and potential 1 renal drug - drug interactions with selected
نویسندگان
چکیده
1 renal drug-drug interactions with selected antivirals 2 3 František Trejtnar, Jana Mandíková, Jana Kočíncová, Marie Volková 4 5 Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Department of 6 Pharmacology and Toxicology, Hradec Kralove, Czech Republic 7 8 Corresponding author: Tel: +420 495 067 436; Fax: +420 495 067 170; E-mail: 9 [email protected] 10 11 Running title: Renal handling of amphotericin B 12 13
منابع مشابه
Renal handling of amphotericin B and amphotericin B-deoxycholate and potential renal drug-drug interactions with selected antivirals.
Amphotericin B (AmB) is excreted via the renal excretion route. This excretion process may result in nephrotoxicity. However, relevant information on the precise renal excretion mechanisms is not available. The aim of the study was to analyze the possible interaction of AmB or its prodrug AmB deoxycholate (AmB-DOC) with the typical renal organic anion transporters (OATs) and organic cation tran...
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متن کاملInfluence of amphotericin B deoxycholate or amphotericin B colloidal dispersion on renal tubule epithelium in rat.
Amphotericin B deoxycholate (AmB) or Amphotericin B colloidal dispersion (ABCD) are used in clinics for the treatment of systemic fungal infections. The goal of our study was to compare the nephrotoxicity of these drugs in rat kidney. The effects of AmB and ABCD on the ultrastructure of the epithelium of renal tubules were studied and evaluated using morphometric and statistical methods. Two gr...
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تاریخ انتشار 2014